SFI Seminar: Compositional Complexity in Genomic Patterns and Classification

Somdatta Sinha

SFI News:

The Santa Fe Institute (SFI) will host a seminar with Somdatta Sinha of the Indian Institute of Science Education and Research (IISER) in Mohali, India.

The seminar is scheduled for 12:15 p.m., Monday, July 7, in the Collins Conference Room at the Santa Fe Institute.

Abstract: Genomes are made of sequences of four nucleotides, A, T, C, and G. Several processes such as mutation, transposition, recombination, translocation, and excision introduce variations in these sequences, which then become the substrates of selection and consequent evolution. Yet different patterns of nucleotide sequences are known to occur in genomes of different species. Such patterns (“genomic signatures” or words) are an emerging area of study in biology. Long range correlations are also known to exist in genomes at different length scales, and genome sequences have been shown to be multi-fractals.

Sinha will discuss how these genomic patterns can be used for classification of closely related genomes. This points towards the role of higher order word structures carrying some meaning in the DNA language. Given that repeats, motifs, etc., are increasingly being found to play important roles in the elaboration of the encoded information in DNA, and regulation of gene expression, Sinha will look into this interplay of complex word structures and biological information processing.  

Note: No lunch will be served; attendees are invited to bring their own.

Click here to view the online event listing.

The Santa Fe Institute is a nonprofit research center located in Santa Fe, New Mexico. Its scientists collaborate across disciplines to understand the complex systems that underlie critical questions for science and humanity. The Institute is supported by philanthropic individuals and foundations, forward-thinking partner companies, and government science agencies.



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