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SFI Seminar: Energy Tradeoffs Between Metabolism, Growth, and Longevity

on October 9, 2012 - 7:52am

SFI News:

The Santa Fe Institute presents "Energy Tradeoffs between Metabolism, Growth, and Longevity" at 12:15 p.m. Thursday Oct. 11 in the Medium Conference Room.

Chen Ho of the Department of Biological Sciences, Missouri University of Science and Technology is conducting the seminar.

Abstract: Diet restriction (DR) and genetic interference (GI) with growth hormone function lead to smaller adult body mass and extended lifespan in mammals, suggesting tradeoffs between growth and longevity.

Despite a rich body of empirical data, still largely missing is a theoretical framework that specifies and makes quantitative predictions on the tradeoffs. In this talk I will present a simple mechanistic model, which predicts that, in the same way, DR and GI channel extra metabolic energy to somatic maintenance by altering animal’s energy budget and suppressing growth, thereby extending lifespan.

The model derives a quantitative relationship between lifespan extension and body mass reduction. Empirical data collected from a diverse set of studies on DR and GI strongly supports the prediction.

The detailed energy tradeoffs revealed by the model offers an answer to the long-standing question raised by the free-radical theory of aging, why DR and GI animals live much longer without largely lowering their metabolic rates.

Note: We are unable to accommodate members of the public for SFI's limited lunch service; you're welcome to bring your own.

SFI Host: Geoffrey West http://www.santafe.edu/gevent/detail/public/1139/

The Santa Fe Institute's mission is to foster a transdisciplinary research community that endeavors to expand the boundaries of scientific understanding.

Its aim is to discover and comprehend the common fundamental principles in physical, computational, biological, and social systems that underlie many of the most profound problems facing science and society today.


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